One Quickie

Preventing Safari from displaying PDFs (WebKit->General)
I loathe using Safari to read PDFs. To tell Safari to stop it, try doing
% defaults write WebKitOmitPDFSupport -bool YES
if you have the misfortune of having the Acrobat Reader plug-in, you can nuke /Library/Internet Plug-Ins/AdobePDFViewer.plugin

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Advanced Mac OS X Programming book